The world's largest base-isolated building

Will humans still be alive on Earth in the year 3000?
If not, why not? Because of religious/spiritual events, nuclear
holocaust, environmental destruction, a move to another planet,
asteroid collision, or something else?

- Arnold, Elizabeth and Rod Beckstrom. Brainticklers: Beyond Y2K - Questions for the New Millenium and the Year 3000. San Francisco: Brainticklers Publishing, 1999, p. 76.